BispebjergHospital_1913-38

40 Der er jo imidlertid ikke noget mærkeligt i, at Medicin kan have en skadelig Virkning paa Organismen: De fleste a f de mest værdi­ fulde af vore Lægemidler er mer eller mindre giftige, uden at man derfor undlader at bruge dem. Man maa blot bruge dem paa rette Maade. Det samme gælder Paraffinolien; den skal ikke forkætres, men man skal anvende den under behørig Kontrol. Man kan maaske til Dels undgaa Ulemperne ved Paraffinolien ved at give den i en vis Afstand fra Maaltiderne som foreslaaet a f Jackson. Man skulde synes, at man ved f. Eks. at give Paraffinolien paa fastende Hjerte eller sent om Aftenen opnaaede, at den først naaede Tarmindhold i Tyktarmen, saaledes at Fødens Vitaminind­ hold var resorberet inden Paraffinolien kom til. Det er imidlertid kun Teori, hvis Berettigelse fremtidige Under­ søgelser maa afgøre. Foreløbigt kan vi sammenfatte Resultaterne a f disse Undersøgelser og sige: Paraffinolie bør gennem længere Tid kun gives til Patienter, om hvem man med Sikkerhed ved, at de lever paa en A-Vitamin-rigelig Kost, og den bør gives i stor Afstand fra Maaltiderne, specielt fra de Maaltider, der er særlig A-Vitamin-holdige. Paraffinolie bør ikke gennem længere Tid gives til Patienter med Resorptionsvanskeligheder. Summary. A series of animal experiments are referred, in which it was de­ monstrated that oral administration of paraffin oil had a pronoun­ ced inhibitory effect upon the utilisation of carotene, and a similar, if somewhat less pronounced effect upon the utilisation of vitamin A. It is generally assumed that paraffin oil acts by sweeping part of the A substances out of the intestine. The difference in effect upon vitamin A and carotene is presumably due to a difference in utilisation between these two substances. Animal experiments have demonstrated that vitamin A is almost completely utilised, whilst 45-65 per cent of the carotene may be found in the stools. Similar observations have been made in man (Boiler, Brunner and Grant) If, however, large doses of vitamin A are administered, this sub­ stance may be excreted in the stools. Excretion generally begins 12-30 days after administration of vitamin A has been commenced (Wendt). Author's own investigations. As it has been demonstrated that fairly large amounts of carotene are normally excreted in the stools, it seemed most suitable to examine the effect of paraffin oil upon the excretion of vitamin A. Vitamin A has been determined in the stools photometrically with Car-Price’s reagent in chloroform ex­ tract after saponification. In order to obtain identical experimental